Spatial Phenotyping with Akoya Biosciences

Spatial Phenotyping with Akoya Biosciences

GeneWorks is happy to announce that we have partnered with Akoya Biosciences® to bring you an exciting technology for spatial biology.

 

Akoya offers two complementary platforms:

CODEX® Solution for hypothesis-free biomarker discovery.

Phenoptics™ Solution for hypothesis-driven biomarker discovery and high-throughput translational research.

  
  

Why Spatial Biology?

Traditional immunohistochemistry (IHC) preserves spatial context but is limited to 2 to 3 biomarkers per sample. Next-generation sequencing enables the analysis of multiple biomarkers but the spatial context of the tissue is lost.

 

Spatial biology (multiplex IHC) addresses these limitations by enabling the analysis of multiple biomarkers in a tissue section while preserving their spatial context to visualise how they organise and interact to influence disease progression and treatment response.  

  

CODEX® - Customisable panels of up to 40+ CODEX®Antibodies to be combined for a single tissue staining reaction.

Phenoptics - Simultaneously detect 8 biomarkers plus DAPI within a single tissue section.

 
 
 
Key publications:
1. Schürch, C. M. et al (2020). Coordinated Cellular Neighborhoods Orchestrate Antitumoral Immunity at the Colorectal Cancer Invasive Front. Cell182(5), 1341–1359 e19  https://doi.org/10.1016/j.cell.2020.07.005
2.Tan, W. et al (2020). Overview of multiplex immunohistochemistry / immunofluorescence techniques in the era of   cancer immunotherapy. Cancer communications (London, England)40(4), 135–    153 https://doi.org/10.1002/cac2.12023
3.De Angelis, C. et al (2020). Evaluation of the Predictive Role of Tumor Immune Infiltrate in Patients with HER2-Positive Breast Cancer Treated with Neoadjuvant Anti-HER2 Therapy without Chemotherapy. Clinical cancer research : an official journal of the American Association for Cancer Research26(3), 738–745 https://doi.org/10.1158/1078-0432.CCR-19-1402
 

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