Cytokine 3-Plex B (TNF-alpha, IL-6, IL-17A) - Simoa Assay - 96 tests

Product Code: QTX-101319

Pack Size: 1 unit

Human tumor necrosis factor alpha (TNFa) is a homotrimeric transmembrane protein that functions as a proinflammatory cytokine. It is produced mainly by macrophages but also by a variety of other cell types, including monocytes, neutrophils, and T-cells and is linked to such diverse functions as acute inflammation, apoptosis, septic shock, cellular proliferation, and differentiation.The clinical relevance of TNFa stems from its association with numerous disease states including rheumatoid arthritis, cancer, cachexia, and Crohn’s disease.

Interleukin 6 (IL-6) is an alpha-helical cytokine with a wide variety of biological functions, including inducement of acute phase reactions, inflammation, hematopoiesis, bone metabolism, and cancer progression. Because of its role in inducing inflammation and auto-immune response, there is interest in developing anti-IL-6 agents as potential therapies against various diseases, including rheumatoid arthritis and cancer.

A major role of IL-17A is its involvement in inducing and mediating proinflammatory responses. The IL-17 family has been linked to many immune/autoimmune related diseases including rheumatoid arthritis, asthma, lupus, allograft rejection, anti-tumor immunity and recently Psoriasis. Because of its involvement in autoimmune conditions, IL-17 inhibitors are being investigated as possible treatments.